Journal Feed Weekly Wrap Up

We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter. 

Originally published at JournalFeed, a site that provides daily or weekly literature updates. 

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#1: A Real-Life Analysis of Paxlovid – Does It Work?

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In the omicron era, nirmatrelvir/ritonavir (Paxlovid) is highly effective in reducing the risk of severe COVID-19 and mortality.

Source
Effectiveness of Paxlovid in Reducing Severe COVID-19 and Mortality in High Risk Patients. Clin Infect Dis. 2022 Jun 2;ciac443. doi: 10.1093/cid/ciac443. Online ahead of print.


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Given the prevalence of serious infection, this review suggests hypothermic infants (<36.5oC, 97.7oF) ages 60 days or younger need a sepsis workup.

Source
The Prevalence for the Risk of Serious Infection in Hypothermic Infants ≤ 60 Days: A Systematic Review. Acad Emerg Med. 2022 Jun 6. doi: 10.1111/acem.14547. Online ahead of print.

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Registry study data finds the criteria to start extracorporeal cardiopulmonary resuscitation (ECPR) of age <75, time from emergency call to hospital arrival within 45 minutes and initial shockable rhythm to be predictive of good neurological outcomes and survival at one month.

Source
Clinical outcomes among out-of-hospital cardiac arrest patients treated by extracorporeal cardiopulmonary resuscitation: The CRITICAL study in Osaka. Resuscitation. 2022 Jun 14:S0300-9572(22)00568-8. doi: 10.1016/j.resuscitation.2022.06.007. Epub ahead of print.


#4: Pre-AeRATE RCT – HFNC 60L vs NC 15L for Apneic Oxygenation

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There was no benefit to using high-flow nasal cannula (HFNC) at 60L/min vs regular NC at 15L/min for pre- and apneic oxygenation during emergency department (ED) intubations.

Source
Pre- and apnoeic high-flow oxygenation for rapid sequence intubation in the emergency department (the Pre-AeRATE trial): A multicentre randomised controlled trial. Ann Acad Med Singap. 2022 Mar;51(3):149-160. doi: 10.47102/annals-acadmedsg.2021407.

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