Welcome back to the EM Educator Series. These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation and management of the specific condition discussed. This week we have a case where you should assume bleeding until proven otherwise.

A 44-year-old female comes to the ED with left lower extremity swelling. The patient notes increased swelling and discoloration to her entire left leg for three days, associated with aching pain. In a patient without any risk factors for thrombus or any other medical reason for hypercoagulability, what could cause an unprovoked left lower extremity thrombus?

Cytokine storm, neurotoxicity, autoimmune reactions... These are just several complications of CAR T-cell therapy. But what is this therapy to begin with? This post evaluates this relatively new cancer therapy and its potential complications.

What do you know about portal vein thrombosis? This post provides you with a comprehensive review of this potentially dangerous condition.

Novel oral anticoagulants are increasingly being used, but what happens if rapid reversal is required? What are your options?

A 46-year-old female presents to your ED with a complaint of abdominal pain and fullness for several weeks and a family history of "blood clots". Could this be Budd Chiari syndrome?

A 37-year-old trauma patient, involved in a motor vehicle collision six hours prior to arrival and stabilized at a county hospital, is transferred to your ED. A nurse notes blood oozing from the man's central and peripheral lines. What laboratory studies do you order? If you're in need of a refresher, take a look at this week's review of disseminated intravascular coagulation.

This post provides key pearls and pitfalls in the evaluation and management of hemochromatosis.