Chronic myelogenous leukemia (CML) is a hematological malignancy that affects the leukocyte cell lineage. On occasion, a life threatening blast crisis can occur. CML is an important diagnosis for emergency physicians to be aware of so that they can manage complications that may occur. This is a brief review of CML and the management of several complications.

Immune Thrombocytopenic Purpura (ITP) is an immune-related cause of low platelet levels. It is more common in children than adults, but may occur in both populations. This is a brief review of the signs and symptoms of ITP and initial treatment options in the emergency department.

Disseminated Intravascular Coagulation (DIC) is a serious complication of some critical illnesses. Patients are very ill and can present with a multitude of symptoms. While treatment of the underlying illness is key, there are some key interventions that can be initiated in the emergency department (ED). This is a brief review of the the underlying pathophysiology of DIC and the interventions that can be initiated in the ED.

Hemolytic anemia is the premature destruction of RBCs, which can be classified as extrinsic or intrinsic, as well as acute or chronic. In particular, several conditions associated with these anemias can cause significant morbidity and mortality. The ED provider must focus on resuscitation, followed by recognition of the hemolytic process and initiation of appropriate therapy. This post will highlight an approach to evaluation and management of hemolytic anemias.

When was the last time you reviewed the literature regarding Heparin-Induced Thrombocytopenia (HIT)? If it's time for a refresher and a few tips regarding ED management, the following post is for you.

A commonly ordered test in the ED is the coagulation panel. What does this panel entail? Is there any evidence behind it for ED use? When should it be ordered? This post provides these answers and more.

Learn the complete ED management of acute complications in sickle cell patients

"Balance between bleeding and thrombosis"

Novel medications like dabigatran and rivaroxaban are increasingly being used to treat patients requiring anticoagulation, but management of bleeding can be a real challenge. Jake Rabe, MD discusses recent trials and reversal strategies.