Hemolytic anemia is the premature destruction of RBCs, which can be classified as extrinsic or intrinsic, as well as acute or chronic. In particular, several conditions associated with these anemias can cause significant morbidity and mortality. The ED provider must focus on resuscitation, followed by recognition of the hemolytic process and initiation of appropriate therapy. This post will highlight an approach to evaluation and management of hemolytic anemias.