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Journal Feed Weekly Wrap-Up

We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter.
Originally published at JournalFeed, a site that provides daily or weekly literature updates.
Follow Dr. Clay Smith at @spoonfedEM, and sign up for email updates here.

#1: How Does Cryoprecipitate Fit into Trauma Resuscitation?

Spoon Feed —
If you have access to the common massive transfusion protocol (MTP) cooler construct of 6:6:1 PRBCs:FFP:platelets, cryoprecipitate should be used at about the start of the second cooler.

Source
Where does cryoprecipitate fit into balanced resuscitation? An evaluation of 2,117 hemorrhaging patients using viscoelastic-based resuscitation. J Trauma Acute Care Surg. 2025 Jul 1;99(1):73-78. doi: 10.1097/TA.0000000000004643. Epub 2025 Apr 17. PMID: 40249632

#2: Wait… Antithrombotics NOT Associated with ICH?

Spoon Feed —
Not everything that can bleed will bleed. This retrospective study of elderly mild-TBI patients showed no significant association between antithrombotic medication use and risk of traumatic ICH.

Source
Association between antithrombotic medications and intracranial hemorrhage among older patients with mild traumatic brain injury: a multicenter cohort study. Eur J Emerg Med. 2025 Jul 1. doi: 10.1097/MEJ.0000000000001246. Epub ahead of print. PMID: 40590793

#3: Twice is Nice? Cephalexin BID for UTI

Spoon Feed — 
In this retrospective study of ED-diagnosed UTIs, Cephalexin dosed twice daily was just as effective as four times daily, with no significant difference in treatment failure – suggesting BID dosing may be a practical, adherence-friendly option in some patients.

Source
Cephalexin twice daily versus four times daily for the treatment of urinary tract infections diagnosed in the emergency department. Am J Emerg Med. 2025 Jul;93:80-85. doi: 10.1016/j.ajem.2025.03.058. Epub 2025 Mar 24. PMID: 40184663

 

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