#1: RSI RCT – Finally an Answer to Ketamine vs Etomidate!
Spoon Feed —
There was no difference in 28-day mortality in critically ill adult patients with ketamine vs. etomidate for rapid sequence induction (RSI), but ketamine increased the need for peri-intubation vasopressor support.
Source
RSI Investigators and the Pragmatic Critical Care Research Group. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2025 Dec 9. doi: 10.1056/NEJMoa2511420. Epub ahead of print. PMID: 41369227.
#2: Do We Really Need an Arterial Line?
Spoon Feed —
The EVERDAC trial found delayed invasive blood-pressure monitoring to be noninferior to early arterial catheterization in patients with shock in terms of 28-day mortality.
Source
CRICS-TRIGGERSEP F-CRIN Network and the EVERDAC Trial Group. Deferring Arterial Catheterization in Critically Ill Patients with Shock. N Engl J Med. 2025 Nov 13;393(19):1875-1888. doi: 10.1056/NEJMoa2502136. Epub 2025 Oct 29. PMID: 41159885.
