#1: NIPPV and Lower Mortality in Severe Asthma
Spoon Feed —
This retrospective, propensity-matched study of adult and pediatric patients with severe asthma confirms what we already know clinically: non-invasive positive pressure ventilation (NIPPV) decreases mortality and need for intubation.
Source
Association Between Noninvasive Positive Pressure Ventilation Use and Clinical Outcomes During a Severe Asthma Exacerbation: A Cohort Study. Crit Care Med. 2026 Jan 14. doi: 10.1097/CCM.0000000000007025. Epub ahead of print. PMID: 41532815.
#2: Is CT Accurate for Globe Rupture?
Spoon Feed —
When eye exam is limited by trauma, we rely on orbital CT. While specificity is 94%, sensitivity is only 75% for open globe injuries (OGI), making surgical consultation necessary when suspicion remains.
Source
Diagnostic test accuracy of CT for open globe injury: A systematic review and meta-analysis of overall impression and individual imaging signs. Injury. 2026 Jan 10;57(3):113041. doi: 10.1016/j.injury.2026.113041. Epub ahead of print. PMID: 41534455.
#3: Non-IV (PO or IN) Ketamine for Pediatric Sedation?
Spoon Feed —
This systematic review suggests that non-injectable ketamine (oral or intranasal) can provide effective and safe pediatric procedural sedation, particularly compared with other oral agents, although the certainty of evidence is low.
Source
Non-Injectable Ketamine for Pediatric Sedation in the Emergency Department: A Systematic Review.Acad Emerg Med. 2025 Dec;32(12):1344-1355. doi: 10.1111/acem.70163. Epub 2025 Oct 10. PMID: 41069251.