#1: LR or NS for Sickle Cell Pain Crisis?
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For sickle cell patients (particularly Hgb SS) with a vaso-occlusive episode (VOE), large volume resuscitation (>2L) with lactated ringers (LR) has been shown to have improved outcome measures compared to normal saline (NS).
Source
Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes. JAMA Intern Med. 2024 Sep 9:e244428. doi: 10.1001/jamainternmed.2024.4428. Epub ahead of print. PMID: 39250114; PMCID: PMC11385329.
#2: The IV vs IO Debate in OHCA Continues…
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This retrospective observational analysis showed an association with more favorable neurologic outcomes, survival to hospital discharge, and ROSC upon ED arrival, in an IV-first approach compared to humeral IO in out-of-hospital cardiac arrests.
Source
The association of intravenous vs. humeral-intraosseous vascular access with patient outcomes in adult out-of-hospital cardiac arrests. Resuscitation. 2024 Sep;202:110360. doi: 10.1016/j.resuscitation.2024.110360. Epub 2024 Aug 16. PMID: 39154890.
