#1: Large- or Small-Bore Chest Tubes for Hemothorax?
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While there was concern for selection bias in a number of included studies, this systematic review and meta-analysis found that small–bore thoracostomy tubes may be appropriate to use in traumatic hemothorax.
Source
Small versus large-bore thoracostomy for traumatic hemothorax: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2024 Oct 1;97(4):631-638. doi: 10.1097/TA.0000000000004412. Epub 2024 Aug 30. PMID: 39213292.
#2: How High Should We Set IPAP for Non-Invasive Ventilation in COPD?
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This RCT found high-intensity non-invasive positive pressure ventilation (NPPV) in COPD patients with persistent hypercapnia decreased the need for endotracheal intubation according to prespecified criteria.
Source
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial. JAMA. 2024 Sep 16:e2415815. doi: 10.1001/jama.2024.15815. Epub ahead of print. PMID: 39283649; PMCID: PMC11406453.
#3: Triple- or Dual-Therapy for Anticoagulation and Platelet Inhibition?
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Apixaban and a P2Y12 inhibitor* is likely the safest antithrombotic regimen for patients with atrial fibrillation and recent acute coronary syndrome requiring both oral anticoagulation and P2Y12 platelet inhibition.
Source
Antithrombotic Strategies in Atrial Fibrillation After ACS and/or PCI: A 4-Way Comparison From AUGUSTUS. J Am Coll Cardiol. 2024 Sep 3;84(10):875-885. doi: 10.1016/j.jacc.2024.06.022. PMID: 39197976.