#1: PARAMEDIC-3 and IVIO RCTs – IO vs IV Epinephrine for OHCA
Spoon Feed
Two large studies randomizing patients with out-of-hospital-cardiac arrest (OHCA) to either an intraosseous (IO) or intravenous (IV) first approach for access had no difference in 30-day survival or neurologically intact survival.
Sources
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780. doi: 10.1056/NEJMoa2407780. Epub ahead of print. PMID: 39480216
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest. N Engl J Med. 2024 Oct 31. doi: 10.1056/NEJMoa2407616. Epub ahead of print. PMID: 39480221
#2: Albumin for AKI in Septic Shock…or Not
Spoon Feed
Administration of early albumin to patients in septic shock with acute kidney injury (AKI) was associated with worse outcomes.
Source
Comparative Effectiveness of Albumin vs No Albumin on Renal Replacement Therapy and Mortality in Patients With Septic Shock and Renal Impairment. Chest. 2024 Oct 18:S0012-3692(24)05315-7. doi: 10.1016/j.chest.2024.10.012. Epub ahead of print. PMID: 39426720
