Journal Feed Weekly Wrap-Up

We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter.
Originally published at JournalFeed, a site that provides daily or weekly literature updates.
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#1: PARAMEDIC-3 and IVIO RCTs – IO vs IV Epinephrine for OHCA

Spoon Feed
Two large studies randomizing patients with out-of-hospital-cardiac arrest (OHCA) to either an intraosseous (IO) or intravenous (IV) first approach for access had no difference in 30-day survival or neurologically intact survival.

Sources
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780. doi: 10.1056/NEJMoa2407780. Epub ahead of print. PMID: 39480216
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest. N Engl J Med. 2024 Oct 31. doi: 10.1056/NEJMoa2407616. Epub ahead of print. PMID: 39480221

#2: Albumin for AKI in Septic Shock…or Not

Spoon Feed
Administration of early albumin to patients in septic shock with acute kidney injury (AKI) was associated with worse outcomes.

Source
Comparative Effectiveness of Albumin vs No Albumin on Renal Replacement Therapy and Mortality in Patients With Septic Shock and Renal Impairment. Chest. 2024 Oct 18:S0012-3692(24)05315-7. doi: 10.1016/j.chest.2024.10.012. Epub ahead of print. PMID: 39426720

#3: Secondary Signs Point to Pediatric Appendicitis on Ultrasound 

Spoon Feed
In this retrospective study of children younger than 5 years with a nonvisualized appendix on ultrasound, the presence of secondary signs of appendicitis was predictive of both appendicitis and complicated appendicitis.

Source
Presence of Sonographic Secondary Signs Without Visualization of Appendix Is Indicative of Appendicitis in Children Younger Than 5 Years. Pediatr Emerg Care. 2024 Nov 8. doi: 10.1097/PEC.0000000000003297. Epub ahead of print. PMID: 39510101

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