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Journal Feed Weekly Wrap-Up

We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter.
Originally published at JournalFeed, a site that provides daily or weekly literature updates.
Follow Dr. Clay Smith at @spoonfedEM, and sign up for email updates here.

#1: Can We Use PERC-35 to Rule Out PE in Younger Patients?

Spoon Feed
In a meta-analysis of patients with septic shock, starting norepinephrine earlier had no mortality benefit, though heterogeneity and bias limit clinically relevant conclusions.

Source
Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock: A Systematic Review and Meta-Analysis. Chest. 2024 Dec;166(6):1417-1430. doi: 10.1016/j.chest.2024.05.042. Epub 2024 Jul 5. PMID: 38972348

#2: Thrombolytics Before Thrombectomy? 

Spoon Feed
In adult stroke patients eligible for both mechanical thrombectomy and IV thrombolytics (IVT), IVT should be offered and may be administered before thrombectomy.

Source
Use of Thrombolytics for the Management of Acute Ischemic Stroke in the Emergency Department. Ann Emerg Med. 2024 Dec;84(6):e57-e86. doi: 10.1016/j.annemergmed.2024.07.023. PMID: 39578010

#3: Do Pre-op Antibiotics Impact Culture Yield for Septic Arthritis?

Spoon Feed
Preoperative antibiotics significantly decreased the microbiologic yield of operative cultures (10.9%) in patients with native joint septic arthritis.

Source
Effect of Preoperative Antibiotic Therapy on Operative Culture Yield for Diagnosis of Native Joint Septic Arthritis. Clin Infect Dis. 2024 Oct 15;79(4):1062-1070. doi: 10.1093/cid/ciae136. PMID: 38466824

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