#1: Can We Use PERC-35 to Rule Out PE in Younger Patients?
Spoon Feed
In a meta-analysis of patients with septic shock, starting norepinephrine earlier had no mortality benefit, though heterogeneity and bias limit clinically relevant conclusions.
Source
Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock: A Systematic Review and Meta-Analysis. Chest. 2024 Dec;166(6):1417-1430. doi: 10.1016/j.chest.2024.05.042. Epub 2024 Jul 5. PMID: 38972348
#2: Thrombolytics Before Thrombectomy?
Spoon Feed
In adult stroke patients eligible for both mechanical thrombectomy and IV thrombolytics (IVT), IVT should be offered and may be administered before thrombectomy.
Source
Use of Thrombolytics for the Management of Acute Ischemic Stroke in the Emergency Department. Ann Emerg Med. 2024 Dec;84(6):e57-e86. doi: 10.1016/j.annemergmed.2024.07.023. PMID: 39578010
