#1: Azithromycin or Doxycycline + β-lactam for CAP?
Spoon Feed —
Treating community-acquired pneumonia (CAP) with ceftriaxone + azithromycin was associated with a mortality benefit over ceftriaxone + doxycycline.
Source
Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193
#2: OPTPRESS – High MAP Goal in Older Patients with Septic Shock
Spoon Feed —
This randomized control trial of older ICU patients with septic shock in Japan showed higher mortality and more frequent adverse events in patients randomized to a high MAP goal (80-85 mmHg) compared to usual care (65-70 mmHg).
Source
Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med. 2025 May;51(5):883-892. doi: 10.1007/s00134-025-07910-4. Epub 2025 May 13. PMID: 40358717
