#1: Break the Enchantment – Intensive BP Control and Brain Swelling
Spoon Feed —
Intensive blood pressure lowering after thrombolysis in acute ischemic stroke did not significantly reduce brain swelling compared to standard BP management.
Source
Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results. Stroke. 2025 Jun;56(6):1388-1395. doi: 10.1161/STROKEAHA.124.049938. Epub 2025 Apr 3. PMID: 40177745
#2: Liberal vs. Conservative Fluid in Sepsis + CHF
Spoon Feed —
This systematic review and meta-analysis found no significant difference in outcomes between conservative and liberal IV fluid resuscitation strategies in septic patients with CHF, CKD, or cirrhosis, highlighting the need for high-quality randomized trials in these high-risk populations.
Source
Conservative versus liberal fluid resuscitation for septic patients at risk for fluid overload: A systematic review with meta-analysis. J Crit Care. 2025 Jun;87:155045. doi: 10.1016/j.jcrc.2025.155045. Epub 2025 Feb 28. PMID: 40023080
