Journal Feed Weekly Wrap-Up

We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter. 

Originally published at JournalFeed, a site that provides daily or weekly literature updates. 

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#1: LOVIT RCT | Vitamin C in Septic Patients – Is There Much to Love?

Spoon Feed
A double-blind, international, multi-center RCT of septic adult ICU patients found an increased risk of death or persistent organ dysfunction at 28 days with a high dose IV vitamin C regimen.

Source
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15.

#2: Don’t Offend the Highly Sensitive Troponin

Spoon Feed
A single high sensitivity cardiac troponin T (hs-cTnT) measurement less than the limit of quantitation (the lowest reportable concentration) appears to be sufficient in ruling out acute MI in a low risk population.

Source
Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation. Circulation. 2022 Jun 7;145(23):1708-1719. doi: 10.1161/CIRCULATIONAHA.122.059235. Epub 2022 May 10.

Spoon Feed
In children with hypotensive septic shock, there was no 30-day mortality benefit to receiving ≥30 mL/kg isotonic fluid within the first hour.

Source
Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock. Ann Emerg Med. 2022 May 28;S0196-0644(22)00245-1. doi: 10.1016/j.annemergmed.2022.04.008. Online ahead of print.

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