serotonin syndrome

A 40-year-old female with history of depression is brought in by EMS for agitation. On arrival she is confused and diaphoretic. Vitals include temperature of 40°C, BP 150/80, HR 120, and RR 28. Exam is remarkable for muscle rigidity, hyperreflexia, and clonus of the lower extremities. What is the next step in your evaluation and treatment?

How do you differentiate serotonin syndrome and neuroleptic malignant syndrome? This week’s TOXCARD provides several keys to help you on your next shift.