#FOAMtox

The D of ADME Toxicology

The other causes of “idiopathic” paralysis other than Guillain-Barré, think Tox!

“As a medical toxicologist, I have a different take on the world of overdoses. Paracelsus has said ‘All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing poison.’ Paracelsus’ adage is something that all medical toxicologists live by; however, we understand there is much more depth to the art of toxicology than the dose makes the poison.”

The A of ADME Toxicology

In this first of five ToxCard posts on pharmacology, we review the basics of toxicokinetics. “All things are poison and nothing is without poison; only the dose makes a thing not a poison” – Paracelsus (Godfather of toxicology, 1493 – 1541). Stay tuned, the future posts will be on absorption, distribution, metabolism, and elimination.

Disulfiram Reactions… No wine with coprine shrooms, and you won’t feel well at all if you take metronidazole.

L-Carnitine: the MVP of VPA treatment

The lowdown on stingrays – RIP Steve Irwin

Learn about the clinical utility of urine drug screens…

Acute liver failure is a difficult condition to manage, especially with the large number of potential etiologies. How can you optimize your management of these patients based on the best literature? This post from Tim Montrief provides you with key points in the evaluation and management of these patients.