#1: Does Spacer Type Matter in Pediatric Wheezing?
Spoon Feed —
In young children with acute wheezing, use of a higher drug-delivery valved holding chamber was associated with improved clinical outcomes compared to a lower-delivery device, supporting the importance of delivery method in bronchodilator therapy.
Source
Valved Holding Chambers in Young Children With Acute Wheezing: A Randomized Clinical Trial. JAMA Pediatr. 2026 Feb 23:e256479. doi: 10.1001/jamapediatrics.2025.6479. Epub ahead of print. PMID: 41729513; PMCID: PMC12931466.
#2: How Long to Watch After Epi in Anaphylaxis
Spoon Feed —
This review advocates for a risk-stratified observation pathway in those who receive epinephrine for anaphylaxis, from as little as 1-3 hours if low-risk to as high as 6-12 hours if high-risk.
Source
Post-anaphylaxis observation in the ED: a decade of data challenging the traditional 24-hour rule. Int J Emerg Med. 2026 Mar 14;19(1):63. doi: 10.1186/s12245-026-01175-4. PMID: 41832433; PMCID: PMC12990544.
#3: Apixaban vs. Rivaroxaban for Venous Thromboembolism
Spoon Feed —
Rivaroxaban has a higher risk of clinically relevant bleeding compared to apixaban during a 3-month treatment period for acute venous thromboembolism.
Source
Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism. N Engl J Med. 2026 Mar 12;394(11):1051-1060. doi: 10.1056/NEJMoa2510703. PMID: 41812192.