Dermatology

EM@3AM: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

A 55-year-old male presents to the ED for a rash of 2-day duration. He had URI symptoms for 4 days preceding the rash with myalgias and subjective fevers. He notes the rash began as small painless, erythematous papules but has progressed to larger, tender bullae. The rash began on his trunk and has spread to his face and bilateral upper extremities. He is febrile and tachycardic. On physical exam, the rash affects close to 20% of TBSA, and with gentle rubbing, skin sloughing is noted. What is the diagnosis?

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Drug Rashes: Not always so simple…

Drug reactions are commonly managed in the ED. Approximately 90-95% of all drug rashes are “drug-induced exanthems”, or morbilliform or maculopapular drug eruptions. Widespread erythematous macules or papules appearing a week after drug exposure are usual. However, drug rash severity varies drastically. This post will cover conditions ranging from the simple drug rash to the deadly DRESS and TEN.

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